Cadence Design Systems

Cadence Design Systems is a global leader in computational software and intelligent system design. While traditionally focused on Electronic Design Automation (EDA) for semiconductors, the company has significantly expanded into the pharmaceutical and biotechnology sectors following its $500 million acquisition of OpenEye Scientific in 2022. This division, now known as Cadence Molecular Sciences (CMS), provides advanced physics-based and AI-driven molecular modeling and simulation tools. Through its flagship cloud-native SaaS platform, Orion, Cadence enables pharmaceutical researchers to conduct massive-scale virtual screening, molecular dynamics, and ligand-based drug discovery. The company serves 19 of the top 20 global pharmaceutical companies, providing the computational infrastructure and algorithms necessary to identify and optimize therapeutic candidates. In late 2025, Cadence further integrated its hardware and software offerings by making Orion available on the Millennium M2000 supercomputer, enabling discovery tasks to be completed in minutes rather than days.