Holostem S.r.l.
↗Modena, Italy
Holostem S.r.l. (formerly Holostem Terapie Avanzate) is a leading Italian biotechnology company specializing in the development, manufacture, and distribution of Advanced Therapy Medicinal Products (ATMPs) based on epithelial stem cells. Founded in 2008 as a spin-off of the University of Modena and Reggio Emilia, the company is world-renowned for developing Holoclar, the first stem cell-based therapy to receive regulatory approval in Europe.
Following a period of financial instability and potential liquidation in 2023, Holostem was acquired and rescued by ENEA Tech and Biomedical (a foundation-backed entity) to ensure the continued availability of its life-saving therapies. The company operates out of a state-of-the-art 2,000-square-meter GMP facility in Modena, focusing on regenerative medicine for rare diseases like Epidermolysis Bullosa and severe ocular conditions.
CLASSIFICATION
SIZE & FINANCIALS
Employees:51-200
Revenue:$1M-$10M
Founded:2008
Ownership:subsidiary
Status:operating
FUNDING
Stage:Acquired
Total Raised:Not disclosed
Investors:ENEA Tech and Biomedical, Fondazione Telethon (Supportive role), Chiesi Farmaceutici (Former majority stakeholder)
PIPELINE
Stage:Commercial
Lead Drug Stage:Commercial
Modalities:Cell therapy, Gene therapy, Retroviral vectors
Active Trials:3
Trial Phases:Phase 1: 2 | Phase 2: 1
FDA Approvals:0
EMA Approvals:1
CORPORATE STRUCTURE
Parent Company:ENEA Tech and Biomedical
Acquired By:ENEA Tech and Biomedical (2023-12-01)
Key Partnerships:University of Modena and Reggio Emilia (Academic partner), Fondazione Banca degli Occhi del Veneto (Strategic distribution & R&D), Fondazione Telethon (Rare disease research)
COMPETITION
Position:Niche Player
Competitors:Krystal Biotech, Mallinckrodt (Stratagraft), Abeona Therapeutics, Amryt Pharma
LEADERSHIP
Key Executives:
Alessandro Padova - CEO & General Manager
Francesco Vetrò - Chairman
Scientific Founders:Michele De Luca, Graziella Pellegrini
Board Members:Francesco Vetrò, Alessandro Padova, Fulvia Astolfi, Massimo Mannella, Maria Luisa Nolli
LINKS
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