Flare Therapeutics
↗Cambridge, MA, USA
Flare Therapeutics is a precision oncology biotechnology company founded in 2021 and headquartered in Cambridge, Massachusetts. The company has developed a novel proprietary platform for discovering and developing small molecule medicines that target transcription factors—a previously challenging drug target class. The platform is founded on the identification of novel druggable pockets called 'switch sites' within transcription factor complexes to solve for where to drug and how to tune gene expression. Flare's approach leverages proteomics and mass spectrometry powered by a proprietary library of electrophilic compounds.
CLASSIFICATION
SIZE & FINANCIALS
Employees:51-200
Founded:2021
Ownership:private
Status:operating
FUNDING
Stage:Series B
Total Raised:$205M
Investors:Third Rock Ventures, Boxer Capital, Nextech Invest, Casdin Capital, Invus Financial Advisors, Eventide Asset Management, GordonMD Global Investments LP, Pfizer Ventures, Agent Capital, Eli Lilly and Company, Memorial Sloan Kettering Cancer Center, Novartis, Pavilion Capital, ShangBay Capital
PIPELINE
Stage:Phase 1-1B
Lead Drug Stage:Phase 1B (dose expansion)
Modalities:Small molecule inhibitors, Transcription factor inhibitors, Covalent inverse agonists
Active Trials:2
Trial Phases:Phase 1: 2
FDA Approvals:0
EMA Approvals:0
CORPORATE STRUCTURE
Key Partnerships:Roche, Caris Life Sciences, Merck
COMPETITION
Position:Leader
Competitors:Jazz Pharmaceuticals, Moderna, Advanced Accelerator Applications, NexImmune, Cullgen, Exo Therapeutics, Edgewise Therapeutics, SEngine Precision Medicine
LEADERSHIP
Key Executives:
Douglas Manion, M.D., FRCP(C) - Chief Executive Officer
Daphne Karydas - President and Chief Financial Officer
Michaela Bowden, Ph.D. - Chief Development Officer
Michael L. Meyers, M.D., Ph.D. - Chief Medical Officer
Jim Audia, Ph.D. - Executive Vice President, Drug Discovery & Early Development; Founding Scientist
Scientific Founders:Fraydoon Rastinejad, Ph.D. (Co-founder), Steven McKnight, Ph.D. (Co-founder, Chair of Scientific Advisory Board), Robert Sims, Ph.D. (Co-founder, Chief Scientific Officer), Jacob Stuckey (Senior Director Biochemistry and Chemical Biology; Founding Scientist)
Board Members:Anna Protopapas (Board Chair), Abbie Celniker, Ph.D. (Board Member)
LINKS
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