eGenesis
↗Cambridge, USA
eGenesis is a clinical-stage biotechnology company pioneering a genome engineering-based approach to develop human-compatible engineered organs, tissues, and cells to address the severe global organ shortage. The company utilizes a proprietary multiplex gene editing and genome engineering platform (EGEN™) to address cross-species molecular incompatibilities and viral risks, aiming to transform the field of xenotransplantation.
The company is advancing a pipeline of programs targeting kidney transplantation, acute liver failure, and heart transplantation. eGenesis has achieved significant milestones, including the successful transplantation of genetically engineered porcine kidneys into human patients under expanded access programs and receiving FDA clearance for clinical trials for its lead kidney program, EGEN-2784.
CLASSIFICATION
SIZE & FINANCIALS
Employees:51-200
Revenue:$10M-$50M
Founded:2015
Ownership:private
Status:operating
FUNDING
Stage:Series D
Total Raised:$481M
Investors:Lux Capital, Khosla Ventures, ARCH Venture Partners, Leaps by Bayer, Fresenius Medical Care Ventures, DaVita, Eisai Innovation, NATCO Pharma, Farallon Capital Management, Alta Partners
PIPELINE
Stage:Phase 1/2/3
Lead Drug Stage:Phase 1/2/3
Modalities:Gene editing, Xenotransplantation, Cell therapy
Active Trials:1
Trial Phases:Phase 1: 1 | Phase 2: 1 | Phase 3: 1
FDA Approvals:0
EMA Approvals:0
CORPORATE STRUCTURE
Subsidiaries:ICBiotec
Key Partnerships:Fresenius Medical Care (strategic investment/collaboration), OrganOx (collaboration on liver perfusion)
COMPETITION
Position:Leader
Competitors:Mammoth Biosciences, Metagenomi, Tessera Therapeutics
LEADERSHIP
Key Executives:
Michael Curtis - CEO
Julie Sunderland - Board Member / Former CEO
Scientific Founders:George Church, Luhan Yang
Board Members:Steven Gillis, Julie Sunderland, Rahul Kakkar
LINKS
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