AskGene
↗Camarillo, California, United States
AskGene Pharma is a clinical-stage biotechnology company founded in 2012 and headquartered in Camarillo, California. The company is pioneering next-generation cytokine therapeutics through its proprietary SmartKine® cytokine prodrug platform, which significantly improves the developability and safety profile of cytokines for oncology and autoimmune/inflammation indications. The company's platform technology enables selective modulation of specific immune cell subsets at the disease site with precision, addressing a major challenge in cytokine therapeutics—the 'cytokine sink' problem that limits efficacy and increases toxicity. AskGene is advancing a pipeline of antibody-cytokine fusion molecules targeting multiple therapeutic areas including gastric/esophageal cancers, autoimmune diseases (lupus, IBD, Type 1 diabetes), and ophthalmological conditions. The company is currently executing its lead Phase III pivotal trial for ASKB589 in China for gastric/gastroesophageal junction cancer.
CLASSIFICATION
Company Type:Biotech
Therapeutic Areas:
Industry:Biotechnology
Sub-Industry:Oncology biotech, Immunotherapy, Cytokine therapeutics
SIZE & FINANCIALS
Employees:1-50
Founded:2012
Ownership:private
Status:operating
FUNDING
Stage:Series A
Total Raised:$37.5M
Investors:Qiming Venture Partners, TF Capital, Beijing Aosaikang Pharmaceutical Co., Ltd.
PIPELINE
Stage:Phase 3
Lead Drug Stage:Phase 3 (ASKB589)
Modalities:Monoclonal antibody, Antibody-cytokine fusion proteins, IL-15 prodrug, IL-2 prodrug, Bispecific antibodies
Active Trials:2
Trial Phases:Phase 1: 1 | Phase 3: 1
FDA Approvals:0
EMA Approvals:0
CORPORATE STRUCTURE
Parent Company:Beijing Aosaikang Pharmaceutical Co., Ltd. (subsidiary)
Key Partnerships:Xilio Therapeutics, GenScript ProBio, Beijing Aosaikang Pharmaceutical
COMPETITION
Position:Emerging
Competitors:Nektar Therapeutics, Amgen, Harpoon Therapeutics, Xilio Therapeutics, Volastra, Loxo Oncology, Ona Therapeutics, Ability Pharma +2 more
LEADERSHIP
Key Executives:
Dr. Jian-Feng Lu - President and Chief Executive Officer
Dr. Barbara Hickingbottom - Chief Medical Officer
Matt Hsu - VP of Preclinical and Clinical Pharmacology
Dr. Stone Shi - Senior Leadership (Process/Development)
Dr. Yuefeng Lu - Senior Leadership (Process Development)
Scientific Founders:Dr. Jian-Feng Lu (CEO & Founder)
LINKS
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