Acelot

South San Francisco, California, USA
VISIT WEBSITE
Acelot is an AI-driven biopharmaceutical company specializing in the discovery and development of small molecule therapeutics for functional protein misfolding diseases. The company combines generative AI, molecular dynamics simulations, and proprietary assays to design novel drugs targeting diseases where misfolded proteins are the root cause. Acelot's platform addresses a significant unmet need in areas like amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), Parkinson's disease, and other neurodegenerative conditions. The company leverages cutting-edge computational chemistry and AI tools to identify and optimize small molecule candidates that restore protein homeostasis, enabling the development of first-in-class and best-in-class therapeutics for devastating diseases where conventional approaches have failed.
CLASSIFICATION
Company Type:Biotech
Therapeutic Areas:
Industry:Biotechnology
Sub-Industry:Neurodegenerative Disease Therapeutics
SIZE & FINANCIALS
Employees:51-200
Founded:2006
Ownership:private
Status:operating
FUNDING
Stage:Series A
Total Raised:$24.2M
Investors:California Life Sciences, U.S. National Science Foundation, U.S. Department of Health and Human Services, University of California, Santa Barbara, National Institutes of Health
PIPELINE
Stage:Preclinical
Lead Drug Stage:IND-enabling studies (2024)
Modalities:Small molecule
Active Trials:0
Trial Phases:-
FDA Approvals:0
EMA Approvals:0
CORPORATE STRUCTURE
Key Partnerships:University of California, Santa Barbara (academic collaboration), NIH/NSF funding relationships
COMPETITION
Position:Emerging
Competitors:AviadoBio - Gene therapies for FTD and ALS, BioArctic - Small molecule and antibody therapeutics for neurodegenerative diseases, Alector - Immunotherapy approaches for Alzheimer's, ALS, and FTD, Athira Pharma - Alzheimer's, Parkinson's, and Lewy body dementia therapies
LEADERSHIP
Key Executives:
Ambuj Singh - CEO & Co-Founder
Christian A. Lang - CTO & Co-Founder
Mike Kavanaugh - Advisor
Scientific Founders:Ambuj Singh, Christian A. Lang
LINKS
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